The All of Us Research Program is a momentous effort to advance individualized prevention, treatment, and care for people of all backgrounds. A consortium led by Columbia University Irving Medical Center and joined by Weill Cornell Medicine, NYC Health + Hospitals/Harlem, and NewYork-Presbyterian is spearheading enrollment in New York City. People ages 18 and older, regardless of health status are eligible to enroll. The All of Us Research Program will enable researchers to more precisely prevent and treat a variety of health conditions.